防止氟化物破坏大脑的香料

2019年4月26日14:57:43防止氟化物破坏大脑的香料已关闭评论 2K
摘要

发表在《生药学》杂志上的一项引人注目的研究,题为”姜黄素减轻氟化物引起的神经毒性:体内证据”,增加了实验支持氟化物确实是一种脑损伤物质的怀疑,也揭示了一种天然香料衍生的保护剂可以抵抗与这种化合物有关的各种健康影响。

防止氟化物破坏大脑的香料

Fluoride is found everywhere today,from antibiotics to drinking water,no stick pans to toothpaste,making exposure inevitable.All the more reason why research proving this common spice can prevent fluoride damage is so promising...

今天,氟化物无处不在,从抗生素到饮用水,从不粘锅到牙膏,使得人们不可避免地接触到氟化物。因此,研究证明这种常见香料具有防止氟化物损害的作用是很有前途的。

Fluoride's neurotoxicity has been the subject of academic debate for decades,and now a matter of increasingly impassioned controversy among the general public,as well.From'conspiracy theories'about it being first used in drinking water in Russian and Nazi concentration camps to chemically lobotomize captives,to its now well-knownIQ lowering properties,to its ability to enhance the calcification of the pineal gland–the traditional'seat of the soul'–many around the world,and increasingly in the heavilyfluoridated regions of the United States,are starting to organize at the local and statewide level to oust this ubiquitous toxicant from municipal drinking water.

几十年来,氟化物的神经毒性一直是学术界争论的话题,现在也成为了公众日益激烈争论的话题。从俄罗斯和纳粹集中营首次将其用于饮用水的阴谋论,到对俘虏进行化学脑叶切除术,再到现在众所周知的降低智商的特性,到加强松果体钙化的能力——松果体是传统的"灵魂之所在"——世界各地的许多地方,以及越来越多的美国高度氟化地区,正开始在地方和全州一级组织起来,将这种无处不在的有毒物质从市政饮用水中排除。

A compelling study published in the Pharmacognosy Magazine titled,"Curcumin attenuates neurotoxicity induced by fluoride:An in vivo evidence,"adds experimental support to the suspicion that fluoride is indeed a brain-damaging substance,also revealing that a natural spice-derived protective agent against the various health effects associated with this compound is available.

发表在《生药学》杂志上的一项引人注目的研究,题为"姜黄素减轻氟化物引起的神经毒性:体内证据",增加了实验支持氟化物确实是一种脑损伤物质的怀疑,也揭示了一种天然香料衍生的保护剂可以抵抗与这种化合物有关的各种健康影响。

The study was authored by researchers from the Department of Zoology,University College of Science,M.L.Sukhadia University,Udaipur,India,who have spent the past decade investigating the mechanisms through which fluoride induces severe neurodegenerative changes in the mammalian brain,particularly in cells of the hippocampus and cerebral cortex.[[i]] [[ii]]

这项研究是由乌代布尔大学科学院动物学系的研究人员撰写的,他们在过去十年中一直在研究氟化物引起哺乳动物大脑中严重的神经退行性变化的机制,尤其是在海马体和大脑皮层的细胞中。[i][ii]

The study opens by describing the historical backdrop for concern about fluoride's significant and wide ranging toxicity:

这项研究通过描述历史背景开始,关注氟化物的重大和广泛的毒性:

"Fluoride(F)is probably the first inorganic ion which drew attention of the scientific world for its toxic effects and now the F toxicity through drinking water is well-recognized as a global problem.Health effect reports on F exposure also include various cancers,adverse reproductive activities,cardiovascular,and neurological diseases.[1,2]"

"氟化物(F)可能是第一个因其毒性效应而引起科学界注意的无机离子,现在通过饮用水产生的 f 毒性已被公认为一个全球性问题。有关氟暴露的健康影响报告还包括各种癌症、不良生殖活动、心血管和神经系统疾病。[1,2]

The study focused on fluoride induced neurotoxicity,identifying excitoxicity(stimulation of the neuron to the point of death)and oxidative stress as the two main drivers of neurodegeneration.It has been observed that subjects with the condition known as fluorosis,a mottling of tooth enamel caused by excessive exposure to fluoride during tooth development,also have neurodegenerative changes associated with a form of oxidative stress known as lipid peroxidation(rancidity).Excess lipid peroxidation in the brain can lead to a decrease in total brain phospholipid content.Owing to these well-known mechanisms of fluoride associated neurotoxicity and neurodegeneration,the researchers identified the primary polyphenol in the spice turmeric--known as curcumin–as an ideal agent worth testing as a neuroprotective substance.Previous research on curcumin indicates that it is capable of activing as an antioxidant in 3 distinct ways by protecting against:1)singlet oxygen 2)hyrodxyl radicals and 3)superoxide radical damage.Also,curcumin appears to raise endogenous glutathione production in the brain,a major antioxidant defense system.

这项研究集中在氟化物引起的神经毒性,确定兴奋性(刺激神经元直至死亡)和氧化应激是神经退行性疾病的两个主要驱动因素。已经有人观察到,患有氟中毒的受试者,也会出现神经退行性变化,这种变化与一种叫做牙齿发育的氧化应激有关。氟中毒是一种在20世纪90年代期间因过度暴露于氟化物而引起的牙釉质斑点病。大脑中过量的脂质过氧化会导致大脑总磷脂含量的下降。由于这些众所周知的氟化物相关神经毒性和神经退行性疾病的机制,研究人员确定香料姜黄中的主要多酚----姜黄素----是一种理想的药剂,值得作为一种神经保护物质进行测试。以前对姜黄素的研究表明,姜黄素能够以三种不同的方式作为抗氧化剂活化:

1)单线态氧

2)hyrodxyl 自由基和

3)超氧自由基损伤。此外,姜黄素似乎可以提高大脑内源性谷胱甘肽的产生,这是一个主要的抗氧化防御系统。

In order to assess the neurotoxic effects of fluoride and prove curcumin's protective role against it,researchers randomly divided up mice into four groups,for 30 days:

为了评估氟化物的神经毒性作用并证明姜黄素对其的保护作用,研究人员将小鼠随机分为四组,为期30:

1.Control(no fluoride)

控制(不含氟化物)

2.Fluoride(120 ppm):fluoride was given in distilled water drinking water without restriction.

氟化物(120ppm):氟化物给予蒸馏水饮用水没有限制

3.Fluoride(120 ppm/30 mg/kg body weight)+Curcumin:Oral dose of curcumin dissolved in olive oil along with fluoride in drinking water

氟化物(120ppm/30mg/kg 体重)+姜黄素:口服剂量姜黄素溶解在橄榄油和氟化物在饮用水

4.Curcumin:(30 mg/kg body weight)

姜黄素:(30毫克/千克体重)

In order to ascertain the effect of treatment,the researchers measured the malondialdehyde(MDA)content in the brains of the different treated mice.MDA is a well-known marker of oxidative stress/damage.

为了确定治疗的效果,研究人员测量了不同治疗小鼠大脑中丙二醛(MDA)的含量。丙二醛(MDA)是氧化应激/损伤的一个众所周知的标志物。

As was expected,the fluoride(F)only treatment group showed significantly elevated MDA levels vs.the non-fluoride treated control.The F+Curcumin group saw reduced MDA levels vs.the fluoride only group,demonstrating curcumin's neuroprotective activity against fluoride associated neurotoxicity.

正如预期的那样,仅氟化物(F)治疗组与未氟化物处理的对照组相比,MDA 水平显著升高。与单纯氟化物组相比,F+姜黄素组的 MDA 水平降低,表明姜黄素对氟化物相关的神经毒性具有神经保护作用。

The study concluded,

研究得出结论:

"Our study thus demonstrate that daily single dose of 120 ppm F result in highly significant increases in the LPO[lipid peroxidation,i.e.brain rancidity]as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions.Supplementation with curcumin significantly reduce the toxic effect of F to near normal level by augmenting the antioxidant defense through its scavenging property and provide an evidence of having therapeutic role against oxidative stress mediated neurodegeneration."

"因此,我们的研究表明,每天单剂量120ppm D 会导致 LPO[脂质过氧化酸败]高度显著增加,以及特定海马区神经元细胞体的神经退行性变化。补充姜黄素可以通过其清除能力增强抗氧化防御功能,从而显著降低 f 的毒性作用至接近正常水平,并提供了对氧化应激介导的神经退行性疾病有治疗作用的证据

Discussion 

讨论

This is far from the first study to demonstrate curcumin's remarkable brain-saving properties.From the perspective of the primary research alone,there are over two hundred peer-reviewed published studies indicating that curcumin is a neuroprotective agent.On our own turmeric database we have 115 articles proving this statement:Turmeric Protects The Brain.We have also featured studies on turmeric's ability to protect and restore the brain:

这远不是第一个证明姜黄素具有显著的脑保护功能的研究。仅从初级研究的角度来看,已经有超过200个同行评审的发表研究表明姜黄素是一种神经保护剂。在我们自己的姜黄数据库中,有115篇文章证明了这一观点:姜黄保护大脑。我们还专门研究了姜黄保护和恢复大脑的能力:

   How Turmeric Can Save the Aging Brain From Dementia and Premature Death

 姜黄如何拯救衰老的大脑免于痴呆和过早死亡

   Turmeric Produces'Remarkable'Recovery in Alzheimer's Patients

姜黄能使阿尔茨海默病患者恢复健康

Considering the many chemical insults we face on a daily basis in the post-industrial world,turmeric may very well be the world's most important herb,with over 800 evidence-based health applications.Visit our Turmeric Research database--the world's largest,open access turmeric resource of its kind--to view the first hand published research on the topi.

考虑到我们在后工业时代每天都要面对许多化学污染,姜黄可能是世界上最重要的草药,有超过800种基于证据的健康应用。访问我们的姜黄研究数据库----世界上最大的开放获取的姜黄资源----查看第一手发表的关于黄姜的研究。

For more information,please review the following content:

欲知详情,请浏览以下内容:

   The Turmeric Drink that Can Revolutionize Your Health

姜黄饮料可以彻底改变你的健康

    Research:Curcumin Is A Triple Negative Breast Killer

研究:姜黄素是一种三重阴性乳腺杀手

   Science Confirms Turmeric As Effective As 14 Drugs

科学证实姜黄与14种药物一样有效

进一步:

 

来源:http://www.greenmedinfo.com/blog/spice-prevents-fluoride-destroying-your-brain

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  • 本文由 发表于 2019年4月26日14:57:43
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