研究:蒲公英叶提取物阻止刺突蛋白与 ACE2细胞表面受体结合

2021年7月8日12:51:04研究:蒲公英叶提取物阻止刺突蛋白与 ACE2细胞表面受体结合已关闭评论 7684831字阅读16分6秒
摘要

德国一所大学的研究发现,西洋蒲公英可以阻止人类肺和肾细胞中刺突蛋白与 ACE2细胞表面受体结合。

研究:蒲公英叶提取物阻止刺突蛋白与 ACE2细胞表面受体结合

The engineered spike proteins from SARS-CoV-2 can be STOPPED by a common"weed"that is exterminated from lawns every year.A German university study found that the common dandelion(Taraxacum officinale)can block spike proteins from binding to the ACE2 cell surface receptors in human lung and kidney cells.The water-based dandelion extract,taken from the plant's dried leaves,was effective against spike protein D614 and a host of mutant strains,including D614G,N501Y,K417N and E484K.

来自 SARS-CoV-2的转基因穗蛋白可以被一种每年从草坪上消灭的普通"杂草"阻止。德国一所大学的研究发现,西洋蒲公英可以阻止人类肺和肾细胞中刺突蛋白与 ACE2细胞表面受体结合。从干燥的蒲公英叶片中提取的水基蒲公英提取物对穗蛋白 D614和一系列突变株,包括 D614GN501YK417N E484K 均有较好的抑制作用。

Dandelion extract blocks SARS CoV-2 spike proteins and their variants

蒲公英提取物阻断 SARS穗蛋白及其变体

The researchers used high molecular weight compounds taken from a water-based dandelion extract and put them to the test in human HEK293-hACE2 kidney and A549-hACE2-TMPRSS2 lung cells.The dandelion blocked the protein-to-protein interactions between the S1 sub unit of the spike protein and the human ACE2 cell surface receptor.This effect was also true against the spike protein mutations from the predominant variants in circulation,including the United Kingdom(B.1.1.7),South African(B.1.351)and Brazilian(P.1)variant.

研究人员从一种水基蒲公英提取物中提取了高分子量的化合物,并在人类 HEK293-hACE2肾脏和 A549-hACE2-TMPRSS2肺细胞中进行了测试。蒲公英阻断了穗蛋白 s 1亚基和人类 ACE2细胞表面受体之间的蛋白质-蛋白质相互作用。对于血液循环中主要变异的穗蛋白突变,包括英国(b.1.1.7)、南非(b.1.351)和巴西(p.1)变异,这种效应也是正确的。

The dandelion extract stopped SARS-CoV-2 spike pseudotyped lentivirus particles from attaching to lung cells and stopped an inflammatory process called interleukin-6 secretion.Because the study was conducted in vitro,further clinical studies are needed to understand how the dandelion extract is absorbed and utilized in biological systems of the human body.

蒲公英提取物阻止了 SARS-CoV-2假型慢病毒颗粒附着在肺细胞上,并阻止了一种称为白细胞介素-6分泌的炎症过程。因为这项研究是在体外进行的,需要进一步的临床研究来了解蒲公英提取物是如何被人体生物系统吸收和利用的。

As vaccines weaken herd immunity,natural herbs promise true prevention,more substantial immunity

由于疫苗削弱了群体免疫力,天然草药承诺真正的预防,更实质的免疫力

Even though tens of billions of public funds have been poured into experimental vaccine development and propaganda campaigns,the world continues to struggle with new respiratory infections,as SARS-CoV-2 is pressured to mutate into different variants.There is no evidence to suggest that coronaviruses can be eradicated from the Earth,so human adaptation will be essential going forward.Dandelion extract is one of many herbs that will assist in a healthy immune response.Better yet,dandelion extract could prove to prevent infections altogether,by blocking the precise channel by which the spike proteins attach and cause viral replication.

尽管数百亿美元的公共资金已投入实验性疫苗开发和宣传活动,但世界仍在与新的呼吸道感染作斗争,因为 SARS-CoV-2被迫变异成不同的变种。没有证据表明冠状病毒可以从地球上根除,所以人类的适应将是必不可少的。蒲公英提取物是许多草药之一,将协助在一个健康的免疫反应。更好的是,蒲公英提取物可以阻断穗蛋白附着和引起病毒复制的精确通道,从而完全预防感染。

Other natural compounds have been investigated using molecular docking studies.Nobiletin is a flavonoid isolated from citrus peels.Neohesperidin,a derivative of hesperetin,is a flavanone glycoside also found in citrus fruits.Glycyrrhizin is a molecular compound extracted from licorice root.All three of these natural substances also block spike proteins from binding to ACE2 receptors.Hydroalcoholic pomegranate peel extract blocks the spike protein at the ACE2 receptor with 74 percent efficacy.When its principal constituents were tested separately,punicalagin was 64 percent effective,and ellagic acid was 36%percent effective.

其他天然化合物已经通过分子对接研究进行了研究。川陈皮素是从柑橘皮中提取的一种黄酮类化合物。新橙皮苷是橙皮素的衍生物,是一种黄烷酮苷,也存在于柑橘类水果中。甘草甜素是从甘草中提取的一种分子化合物。所有这三种天然物质也阻断了穗蛋白与 ACE2受体的结合。水醇石榴皮提取物阻断血管紧张素转换酶2受体的穗蛋白,功效达74%。分别测定其主要成分的有效率为64%,鞣花酸的有效率为36%

These natural compounds(along with dandelion extract)can be readily mass produced,combined and deployed as preventative medicine for all future spike protein variants.These herbs are generally recognized as safe,and there are no known cases of overdose with dandelion leaf extract.According to the European Scientific Cooperative on Phytotherapy,the recommended dosage of dandelion leaf is 4–10 grams steeped in hot water,up to three times per day.

这些天然化合物(连同蒲公英提取物)可以很容易地大规模生产,结合和部署作为预防药物为所有未来的穗蛋白变种。这些草药一般被认为是安全的,并没有已知的情况下与过量蒲公英叶提取物。根据欧洲植物治疗科学合作组织的建议,蒲公英叶的推荐剂量为4-10克,每天最多三次浸泡在热水中。

The study authors warn that reliance on vaccines is risky and dangerous,not just for individual health but also for herd immunity.Vaccine reliance only focuses on antibody augmentation and is proving to be a high-risk intervention with short term results.Vaccine injuries are frequently reported.Re-infections post vaccination are also common,as the vaccine puts pressure on the original engineered spike protein to mutate.

这项研究的作者警告说,依赖疫苗是危险和危险的,不仅对个人健康,而且对群体免疫也是如此。对疫苗的依赖仅仅集中在抗体的增强上,并且被证明是一种具有短期效果的高风险干预。疫苗伤害经常被报道。接种疫苗后再次感染也很常见,因为疫苗对原来的工程化棘突蛋白施加压力使其发生变异。

The authors conclude:"Thus,factors such as low toxicity in humans and effective binding inhibition of five relevant spike mutations to the human ACE2 receptor,as reported here in vitro,encourage for more in-depth analysis of T.officinales'effectiveness in SARS-CoV-2 prevention and now requires further confirmatory clinical evidence."

作者总结道:"因此,正如这里在体外报道的那样,诸如人体低毒性和对人类 ACE2受体5个相关突变的有效结合抑制等因素,鼓励更深入地分析铁线莲在 SARS-CoV-2预防方面的有效性,现在需要进一步的临床证据。"

来源:

https://thetruthaboutvaccines.com/research-dandelion-leaf-extract-blocks-spike-proteins-binding-ace2-cell-surface-receptor/

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  • 本文由 发表于 2021年7月8日12:51:04
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